Berberine HCl
Berberine is a plant alkaloid extracted from barberry and related species, and it is the ingredient the manufacturer leads with. Randomised trials in people with type 2 diabetes have measured lower fasting glucose at roughly 500 mg taken two or three times a day, a total of about 1,000 to 1,500 mg (Endocrine Journal, 2019). What the evidence does not show is that a single undisclosed gummy dose reproduces that result, and berberine is poorly absorbed, which is exactly why trial doses are so large.
